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Showing my age here, I started on a teletype terminal with a card reader for memory.
When I retired from university a couple of years ago I was running about 15 different computers in my lab, most with their own unique software running on every version of Windows from 3.1 to Vista (legacy machines, we couldn't update the hardware because the software wasn't compatible, or vice versa), Macs, Silicon Graphics and some Real Time Operating systems with Microware os9 on a VME bus (just putting this in for the geeks on here!).
Some machines were dual screen, controls on the left, images on the right from the same PC, but the most complicated one had two screens running from two separate PCs, one with Windows 2000 ran a microscope, the other with XP Pro ran a camera, and they all had to talk to each other in the right order. It was great fun trying to explain to a foreign student with limited English, sometimes even harder explaining to an English student with limited intelligence, impossible with some of the professors. Did my head in eventually, there was little room left for many normal thought processes.